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植物代谢组学学科组

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  2. 研究中心与学科组
  3. 特色农业资源植物研究中心

学科组致力于代谢组学分析、质谱数据库构建、代谢组图谱绘制、代谢组学与多学科交叉研究等方面的研究工作。目前，已绘制了首张衰老小鼠的脑代谢组图谱，揭示了脑衰老的代谢基础，为脑疾病及药物调控的脑代谢研究提供了基准数据；构建了脂肪酸羟基脂肪酸酯（FAHFA）衍生物的计算机模拟二级质谱图数据库，收录了4000余种FAHFA衍生物的结构及谱图信息；发展了油菜素甾醇、多胺、赤霉素等重要植物代谢物的高灵敏高通量分析方法。相关研究成果发表于Nature Communications, Analytical Chemistry、Analytica Chimica acta等期刊上，被引2000余次。

研究组长

  姓   名 丁俊 学   历 博士
职   称 研究员 职   务 博士生导师, PI
通讯地址 武汉市东湖新技术开发区九峰一路201号
邮政编码 430074 电子邮箱 dingjun@wbgcas.cn
姓 名： 丁俊
学 历： 博士
职 称： 研究员
职 务： 博士生导师,PI
通讯地址： 武汉市东湖新技术开发区九峰一路201号
邮政编码： 430074
电子邮箱： dingjun@wbgcas.cn
简要履历
2022年-至今 中国科学院武汉植物园，研究员，博士研究生导师
2019年-2020年 加州大学戴维斯分校，基因组中心、NIH西海岸代谢组学中心，博士后
2018年-2019年 芝加哥大学, Ben May癌症研究中心，博士后
2017年-2021年 武汉大学，化学与分子科学学院，分析科学研究中心，副研究员
2015年-2017年 武汉大学，化学与分子科学学院，分析科学研究中心，讲师
2014年-2015年 中国科学院武汉植物园，助理研究员
2009年-2014年 武汉大学，化学与分子科学学院，分析化学博士
2005年-2009年 中山大学，化学与化学工程学院，学士
社会任职
  • Frontiers in Chemistry special issue “Recent Application of Nanomaterials in Sample Preparation”客座编辑；
  • Analytical Chemistry, Analytica Chimica Acta, Journal of Chromatography A, 《分析科学学报》审稿人；
  • Grant proposal for the National Science Center, Poland评审人。

研究组科研项目

  • 湖北省青年拔尖人才培养计划（2023-2025），项目负责人；
  • 国家自然科学基金面上基金项目(2021-2024)，基于化学衍生-计算机模拟二级质谱图数据库策略的酰基辅酶A全分析方法研究，项目负责人；
  • 国家自然科学基金青年基金项目(2017-2019)，基于富勒烯衍生物的MALDI-MS反应性基质研究及其在生物活性小分子快速检测中的应用，项目负责人；
  • 中央高校基本科研业务费专项资金(2016-2017)，基于尿肌氨酸的前列腺癌早期诊断方法研究，项目负责人。

研究组代表成果

代表性论文：
  1. J. Ding, Y. Q. Feng, Mass spectrometry-based metabolomics for clinical study: Recent progresses and applications. TrAC Trends in Analytical Chemistry, 158 (2023) 116896.
  2. J. Sun#, J. Ding#, Q. Shen, X. Wang, M. Wang, Y. Huang, X. Zhang, H. Zhu, F. Zhang, D. Wu, M. Peng, Z. Zhang, Y. Yuan, W. Li, Z-G. She, X. Zhang, H. Li, P. Zhang*, Z. Huang*, Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma. Journal of Hepatology, 2023, DOI 10.1016/j.jhep.2022.11.017. (#Co-first author)
  3. J. Ding, J. Ji, Z. Rabow, T. Shen, J. Folz, C. Brydges, S. Fan, X. Lu, S. Mehta, M. Showalter, Y. Zhang, R. Araiza, L. Bower, K. Lloyd, O. Fiehn*, A Metabolome Atlas of the Aging Mouse Brain, Nature Communications, 12 (2021) 6021.
  4. J. Ding, T. Kind, Q.F. Zhu, Y. Wang, J.W. Yan, O. Fiehn*, Y.Q. Feng*, In-Silico-Generated Library for Sensitive Detection of 2-Dimethylaminoethylamine Derivatized FAHFA Lipids Using High-Resolution Tandem Mass Spectrometry, Analytical Chemistry, 92 (2020) 5960-5968.
  5. L. Yu, J. Ding*, Y.-L. Wang, P. Liu, Y.-Q. Feng*, 4-Phenylaminomethyl-benzeneboric acid modified tip extraction for determination of brassinosteroids in plant tissues by stable isotope Labeling–Liquid Chromatography–Mass spectrometry, Analytical Chemistry, 88 (2015) 1286-1293.
  6. J. Ding, G. Chen, G. Chen*, M. Guo*, One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells, Pharmaceutics, 11 (2019) 123.
  7. J. Ding, H.-M. Xiao, S. Liu, C. Wang, X. Liu, Y.-Q. Feng*, A matrix-assisted laser desorption/ionization mass spectrometry method for the analysis of small molecules by integrating chemical labeling with the supramolecular chemistry of cucurbituril, Analytica Chimica Acta, 1026 (2018) 77-86.
  8. J. Ding, S. Liu, H.-M. Xiao, T.T. Ye, P. Zhou, Y.-Q. Feng*, Matrix-assisted laser desorption/ionization mass spectrometry for the analysis of polyamines in plant micro-tissues using cucurbituril as a host molecule, Analytica Chimica Acta, 987 (2017) 56-63.
  9. J. Ding, X.-T. Luo, Y.-R. Yao, H.-M. Xiao, M.-Q. Guo*, Investigation of changes in endocannabinoids and N-acylethanolamides in biofluids, and their correlations with female infertility, Journal of Chromatography A, 1509 (2017) 16-25.
  10. J. Ding, L.-J. Mao, N. Guo, L. Yu, Y.-Q. Feng*, Determination of endogenous brassinosteroids using sequential magnetic solid phase extraction followed by in situ derivatization/desorption method coupled with liquid chromatography–tandem mass spectrometry, Journal of Chromatography A, 1446 (2016) 103-113.
  11. J. Ding, J.-H. Wu, J.-F. Liu, B.-F. Yuan, Y.-Q. Feng*, Improved methodology for assaying brassinosteroids in plant tissues using magnetic hydrophilic material for both extraction and derivatization, Plant methods, 10 (2014) 39.
  12. J. Ding, L.-J. Mao, B.-F. Yuan, Y.-Q. Feng*, A selective pretreatment method for determination of endogenous active brassinosteroids in plant tissues: double layered solid phase extraction combined with boronate affinity polymer monolith microextraction, Plant Methods, 9 (2013) 13. Phytochemical Analysis, 24 (2013) 386-394.
  13. J. Ding, L.J. Mao, S.T. Wang, B.F. Yuan, Y.Q. Feng*, Determination of Endogenous Brassinosteroids in Plant Tissues Using Solid‐phase Extraction with Double Layered Cartridge Followed by High‐performance Liquid Chromatography–Tandem Mass Spectrometry, Phytochemical Analysis, 24 (2013) 386-394.
  14. J. Ding, Q. Gao, X.S. Li, W. Huang, Z.G. Shi, Y.Q. Feng*, Magnetic solid‐phase extraction based on magnetic carbon nanotube for the determination of estrogens in milk,Journal of separation science, 34 (2011) 2498-2504.
  15. J. Ding, Q. Gao, D. Luo, Z.-G. Shi, Y.-Q. Feng*, n-Octadecylphosphonic acid grafted mesoporous magnetic nanoparticle: Preparation, characterization, and application in magnetic solid-phase extraction, Journal of Chromatography A, 1217 (2010) 7351-7358.
  16. C.F. Xiong, J. Ding#, Q.F. Zhu, Y.L. Bai, X.M. Yin, T.-T. Ye, Q.-W. Yu, Y.-Q. Feng*, Boron Isotope Tag-Assisted Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry for Discovery and Annotation of cis-Diol-Containing Metabolites, Analytical Chemistry, 93 (2021) 3002–3009. (#Co-first author)
  17. P. Wu, H.-M. Xiao, J. Ding*, Q.-Y. Deng, F. Zheng, Y.-Q. Feng*, Development of C60-based labeling reagents for the determination of low-molecular-weight compounds by matrix assisted laser desorption ionization mass (I): Determination of amino acids in microliter biofluids, Analytica Chimica Acta, 960 (2017) 90-100.
  18. D. Chen, J. Ding#, M.-K. Wu, T.-Y. Zhang, C.-B. Qi, Y.-Q. Feng*, A liquid chromatography–mass spectrometry method based on post column derivatization for automated analysis of urinary hexanal and heptanal, Journal of Chromatography A, 1493 (2017) 57-63. (#Co-first author)
  19. X.-M. He, J. Ding*, L. Yu, D. Hussain, Y.-Q. Feng*, Black phosphorus-assisted laser desorption ionization mass spectrometry for the determination of low-molecular-weight compounds in biofluids, Analytical and Bioanalytical Chemistry, 408 (2016) 6223-6233.
  20. D. Zhang, Z. Tang, H. Huang, G. Zhou, C. Cui, Y. Weng, W. Liu, S. Kim, S. Lee, M. Perez-Neut, J. Ding, etc., Yingming Zhao*, Metabolic regulation of gene expression by histone lactylation, Nature, 574 (2019) 575-580.
  21. Y. Fang, X. Xu, J. Ding, L. Yang, M. T., Doan, P. W. F., Karmaus, N. W., Snyder, Y., Zhao; J. L., Li, X. Li*, Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells. Cell Stem Cell, 28 (2021), 748-763.
  22. Z. Zhu, Z. Han, L. Halabelian, X. Yang, J. Ding, N. Zhang, L. Ngo, J. Song, H. Zeng, M. He, Y. Zhao, C. H. Arrowsmith, M. Luo, M. G. Bartlett, Y. G. Zheng*, Identification of lysine isobutyrylation as a new histone modification mark. Nucleic Acids Research, 49 (2021) 177-189.