植物代谢组学学科组

	姓   名	丁俊	学   历	博士
	职   称	研究员	职   务	博士生导师, PI
	通讯地址	武汉市东湖新技术开发区九峰一路201号
	邮政编码	430074	电子邮箱	dingjun@wbgcas.cn

姓 名：	丁俊
学 历：	博士
职 称：	研究员
职 务：	博士生导师,PI
通讯地址：	武汉市东湖新技术开发区九峰一路201号
邮政编码：	430074
电子邮箱：	dingjun@wbgcas.cn

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研究组科研项目

• 国家自然科学基金面上基金项目(22074108, 2021.1-2024.12)，基于化学衍生-计算机模拟二级质谱图数据库策略的酰基辅酶A全分析方法研究，项目负责人；
• 国家自然科学基金青年基金项目(21605117, 2017.1-2019.12)，基于富勒烯衍生物的MALDI-MS反应性基质研究及其在生物活性小分子快速检测中的应用，项目负责人；
• 中央高校基本科研业务费专项资金(2042016kf0035, 2016.1-2017.12)，基于尿肌氨酸的前列腺癌早期诊断方法研究，项目负责人。

研究组代表成果

1. J. Ding, J. Ji, Z. Rabow, T. Shen, J. Folz, C. Brydges, S. Fan, X. Lu, S. Mehta, M. Showalter, Y. Zhang, R. Araiza, L. Bower, K. Lloyd, O. Fiehn^*, A Metabolome Atlas of the Aging Mouse Brain, Nature Communications, 12 (2021) 6021.
2. J. Ding, T. Kind, Q.F. Zhu, Y. Wang, J.W. Yan, O. Fiehn^*, Y.Q. Feng^*, In-Silico-Generated Library for Sensitive Detection of 2-Dimethylaminoethylamine Derivatized FAHFA Lipids Using High-Resolution Tandem Mass Spectrometry, Analytical Chemistry, 92 (2020) 5960-5968.
3. L. Yu, J. Ding^*, Y.-L. Wang, P. Liu, Y.-Q. Feng^*, 4-Phenylaminomethyl-benzeneboric acid modified tip extraction for determination of brassinosteroids in plant tissues by stable isotope Labeling–Liquid Chromatography–Mass spectrometry, Analytical Chemistry, 88 (2015) 1286-1293.
4. J. Ding, G. Chen, G. Chen^*, M. Guo^*, One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells, Pharmaceutics, 11 (2019) 123.
5. J. Ding, H.-M. Xiao, S. Liu, C. Wang, X. Liu, Y.-Q. Feng^*, A matrix-assisted laser desorption/ionization mass spectrometry method for the analysis of small molecules by integrating chemical labeling with the supramolecular chemistry of cucurbituril, Analytica Chimica Acta, 1026 (2018) 77-86.
6. J. Ding, S. Liu, H.-M. Xiao, T.T. Ye, P. Zhou, Y.-Q. Feng^*, Matrix-assisted laser desorption/ionization mass spectrometry for the analysis of polyamines in plant micro-tissues using cucurbituril as a host molecule, Analytica Chimica Acta, 987 (2017) 56-63.
7. J. Ding, X.-T. Luo, Y.-R. Yao, H.-M. Xiao, M.-Q. Guo^*, Investigation of changes in endocannabinoids and N-acylethanolamides in biofluids, and their correlations with female infertility, Journal of Chromatography A, 1509 (2017) 16-25.
8. J. Ding, L.-J. Mao, N. Guo, L. Yu, Y.-Q. Feng^*, Determination of endogenous brassinosteroids using sequential magnetic solid phase extraction followed by in situ derivatization/desorption method coupled with liquid chromatography–tandem mass spectrometry, Journal of Chromatography A, 1446 (2016) 103-113.
9. J. Ding, J.-H. Wu, J.-F. Liu, B.-F. Yuan, Y.-Q. Feng^*, Improved methodology for assaying brassinosteroids in plant tissues using magnetic hydrophilic material for both extraction and derivatization, Plant methods, 10 (2014) 39.
10. J. Ding, L.-J. Mao, B.-F. Yuan, Y.-Q. Feng^*, A selective pretreatment method for determination of endogenous active brassinosteroids in plant tissues: double layered solid phase extraction combined with boronate affinity polymer monolith microextraction, Plant Methods, 9 (2013) 13. Phytochemical Analysis, 24 (2013) 386-394.
11. J. Ding, L.J. Mao, S.T. Wang, B.F. Yuan, Y.Q. Feng^*, Determination of Endogenous Brassinosteroids in Plant Tissues Using Solid‐phase Extraction with Double Layered Cartridge Followed by High‐performance Liquid Chromatography–Tandem Mass Spectrometry, Phytochemical Analysis, 24 (2013) 386-394.
12. J. Ding, Q. Gao, X.S. Li, W. Huang, Z.G. Shi, Y.Q. Feng^*, Magnetic solid‐phase extraction based on magnetic carbon nanotube for the determination of estrogens in milk,Journal of separation science, 34 (2011) 2498-2504.
13. J. Ding, Q. Gao, D. Luo, Z.-G. Shi, Y.-Q. Feng^*, n-Octadecylphosphonic acid grafted mesoporous magnetic nanoparticle: Preparation, characterization, and application in magnetic solid-phase extraction, Journal of Chromatography A, 1217 (2010) 7351-7358.
14. C.F. Xiong, J. Ding^#, Q.F. Zhu, Y.L. Bai, X.M. Yin, T.-T. Ye, Q.-W. Yu, Y.-Q. Feng^*, Boron Isotope Tag-Assisted Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry for Discovery and Annotation of cis-Diol-Containing Metabolites, Analytical Chemistry, 93 (2021) 3002–3009. (#Co-first author)
15. P. Wu, H.-M. Xiao, J. Ding^*, Q.-Y. Deng, F. Zheng, Y.-Q. Feng*, Development of C60-based labeling reagents for the determination of low-molecular-weight compounds by matrix assisted laser desorption ionization mass (I): Determination of amino acids in microliter biofluids, Analytica Chimica Acta, 960 (2017) 90-100.
16. D. Chen, J. Ding^#, M.-K. Wu, T.-Y. Zhang, C.-B. Qi, Y.-Q. Feng^*, A liquid chromatography–mass spectrometry method based on post column derivatization for automated analysis of urinary hexanal and heptanal, Journal of Chromatography A, 1493 (2017) 57-63. (#Co-first author)
17. X.-M. He, J. Ding^*, L. Yu, D. Hussain, Y.-Q. Feng^*, Black phosphorus-assisted laser desorption ionization mass spectrometry for the determination of low-molecular-weight compounds in biofluids, Analytical and Bioanalytical Chemistry, 408 (2016) 6223-6233.
18. D. Zhang, Z. Tang, H. Huang, G. Zhou, C. Cui, Y. Weng, W. Liu, S. Kim, S. Lee, M. Perez-Neut, J. Ding, etc., Yingming Zhao^*, Metabolic regulation of gene expression by histone lactylation, Nature, 574 (2019) 575-580.
19. Y. Fang, X. Xu, J. Ding, L. Yang, M. T., Doan, P. W. F., Karmaus, N. W., Snyder, Y., Zhao; J. L., Li, X. Li^*, Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells. Cell Stem Cell, 28 (2021), 748-763.
20. Z. Zhu, Z. Han, L. Halabelian, X. Yang, J. Ding, N. Zhang, L. Ngo, J. Song, H. Zeng, M. He, Y. Zhao, C. H. Arrowsmith, M. Luo, M. G. Bartlett, Y. G. Zheng^*, Identification of lysine isobutyrylation as a new histone modification mark. Nucleic Acids Research, 49 (2021) 177-189.